Big brains
At approximately age 40, the grey matter size begins to gradually decrease all round the brain, particularly in the prefrontal cortex and hippocampus. The myelin - wrapped around neurons for faster communication - begins to get thinner, decreasing the speed of the brain.
Slower 'thinking'
Cognitive skills, such as making new memories, begin to gradually decrease and 'thoughts' begin to slow - the processing speed decreases.